Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG071
收藏Protein Data Bank Japan2023-10-04 更新2026-03-21 收录
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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG071 Descriptor: 1,2-ETHANEDIOL, 11-[(2R)-butan-2-yl]-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, 11-[(2S)-butan-2-yl]-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, ... Authors: Xu, X, Blacklow, S.C. Deposit date: 2018-02-25 Release date: 2018-08-29 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13, 2018
创建时间：
2018-02-25
