Statin pathway
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Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]
他汀类药物通过竞争性抑制HMG-CoA还原酶（HMGCR），即催化HMG-CoA转化为甲羟戊酸这一胆固醇合成的早期限速步骤的酶，来抑制内源性胆固醇的生成。该途径界定了与他汀类药物治疗基因组学相关的基因，包括那些在调节他汀类药物对血浆脂蛋白代谢的影响中发挥作用的基因。资料来源：[https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] 以及 [http://en.wikipedia.org/wiki/Statin Wikipedia]
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