Construction of Vicinal Tetrasubstituted Stereocenters with a C–F Bond through a Catalytic Enantioselective Detrifluoroacetylative Mannich Reaction
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https://figshare.com/articles/dataset/Construction_of_Vicinal_Tetrasubstituted_Stereocenters_with_a_C_F_Bond_through_a_Catalytic_Enantioselective_Detrifluoroacetylative_Mannich_Reaction/2097364
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资源简介：
An efficient asymmetric detrifluoroacetylative
Mannich reaction
of 2-fluoro-1,3-diketones/hydrates with isatin-derived ketimines catalyzed
by a chiral copper(II)-diamine complex has been realized. The reaction
afforded a series of 3-substituted 3-amino-2-oxindoles bearing fluorine-containing
vicinal tetrasubstituted stereocenters in high yields (up to 99%)
with excellent diastereoselectivities (up to >20:1 dr) and enantioselectivities
(up to 94% ee).
创建时间：
2016-02-12
