Cu-Catalyzed Three-Component Carboamination of Alkenes

Copper-catalyzed
intermolecular carboamination of alkenes with
α-halocarbonyls and amines is presented with 42 examples. Electron
rich, electron poor, and internal styrenes, as well as α-olefins,
are functionalized with α-halocarbonyls and aryl or aliphatic
amines. Mechanistic investigations suggest the reaction is proceeding
through addition of a carbon-centered radical across an olefin followed
by oxidation to form a 5-membered oxocarbenium intermediate and subsequent
nucleophilic ring opening to forge the C–N bond.