Measures of association for advanced AMD with variants characterizing T haplogroups.

Odds ratios (ORs) comparing the proportion of people with variants characterizing the T1 or T2 haplogroups and advanced (Adv.) AMD relative to their AMD-free peers. The mtDNA T1 haplogroup is defined by the presence of the 4917G variant and the presence of the 11812A variant. The T2 haplogroup is defined by the presence of 4917G and 11812G. The multivariable models are adjusted for age, sex, and smoking history (ever vs. never). Models for the AREDS+BMES cohorts contain a term for sample origin (study).*P-values are 2-sided, unless marked with an asterisk; 1-sided P-values (for replication analyses) are for tests on the hypothesis that people with AMD are more likely to carry haplogroup-defining variants. All samples are composed of participants self-identified as being of non-Hispanic white origin. Demographic characteristics of the samples exist in Table S1. AREDS samples A and B are independent. ORs from the meta-analysis are from random effects models. Respective values for T1 and T2 from fixed-effects models are 0.85 (95%CI 0.37�C1.96, 2-sided P