microRNA profiling of fetal lamb heart treated with coiled implantation in left atrium against untreated controls. microRNA profiling of fetal lamb heart treated with coiled implantation in left atrium against untreated controls

We created a fetal lamb model of hypoplastic left heart syndrome (HLHS), by implanting coils in the left atrium in mid-gestation. We performed bulk RNA sequencing of left ventricles (LV), right ventricles (RV), ascending aortae (AAo) and pulmonary arteries (PA). Single nucleus RNA sequencing was performed on LV free wall tissue (n = 4 coiled samples, n = 3 controls).