Expression data from male and female Schlager hypertensive (BPH/2J) and normotensive (BPN/3J) kidneys

Analysis of kidneys from 12 week BPH/2J hypertensive and age matched normotensive BPN/3J controls - males and females. The results provide insights into the genes that are involved in hypertension in both males and females, as well as highlight mechanisms that underlye sex differences in hypertension. We show that female data can be used to refine candidate genes and pathways, as well as highlight potential mechanisms to explain the differences in prevalence and severity of disease between the sexes. Male and female kidneys from 12 week old hypertensive (BPH/2J) and normotensive (BPN/3J) mice were collected for RNA extraction and hybridization on Affymetrix microarrays. We used data obtained from male and female kidneys to identify common genes that are involved in the development of hypertension in males and females本研究针对12周龄高血压模型小鼠BPH/2J与年龄匹配的正常血压对照小鼠BPN/3J的雌雄肾脏组织开展分析。研究结果可揭示雌雄个体高血压发生相关的基因，并阐明高血压性别差异的潜在分子机制。本研究证实，雌性小鼠的组织数据可用于优化高血压相关候选基因与通路，同时进一步阐释可解释雌雄个体间疾病患病率与严重程度差异的潜在机制。我们收集了12周龄高血压模型小鼠BPH/2J与正常血压对照小鼠BPN/3J的雌雄肾脏组织，用于RNA提取及Affymetrix基因芯片杂交实验。本研究利用雌雄肾脏组织的检测数据，筛选出雌雄个体高血压发生发展过程中共有的致病相关基因。