Effect of anti-DENV scFv on fitness.

Comparisons of several fitness parameters (left-most column) between WT (second column from left) and TADV-A mosquitoes (third column from left) suggest that there are few significant differences (right-most column) between the two groups, indicating that the anti-DENV scFv does not have a major impact on mosquito fitness. The survivorship of infected and non-infected mosquitoes is also shown. The median survival in days was determined for non-infected mosquitoes, and the percent of surviving mosquitoes separately infected by four DENV serotypes was assessed at 14 dpi.