Chinese medicine in postoperative adjuvant chemotherapy (Capecitabine therapy) for colorectal cancer: Examination of prevention of hand-foot syndrome by the prophylactic administration of Eppikajutsutou (clinical phase II study)

Interventions: Capecitabine + Eppikajutsutou group One course of Capecitabine: Daily oral administration of Capecitabine (Xeloda) dose according to the body surface area twice a day for 14 days within 30 minutes after the breakfast and the supper, and a rest for seven days afterwards. Total 8 courses are performed. Eppikajutsutou: Daily oral administration during Capecitabine therapy Its dose is 7.5g divided in three times/day, before a meal or inter cibos.
Capecitabine + Vitamin B6 group One course of Capecitabine: It is the same as intervention 1. Vitamin B6: Daily oral administration during Capecitabine therapy Its dose is 60mg divided in three times/day, after a meal.
Primary outcome(s): Incidence rate of hand-foot syndrome of Grade2 or more
Study Design: Parallel Randomized