Additional file 4 of Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights

Supplementary Table 1. Data and sample details of ASD and 8 genetically correlated traits (P 90%, Shown in bold) called on coloc.abf with a window size of ± 50 KB flanking the SNP locus. Supplementary Table 4. (A) Mendelian randomization (MR) results for ASD as outcome and related traits. (B) MR where ASD is the exposure and related traits are the outcome. Supplementary Table 5. MV associated genes are found in systems curated/implicated with gut microbiome and neural systems from GeneCards. Supplementary Table 6. List of 637 Significant SNPs (p < 5e-8), with 315 already reported in the GWAS catalog, identified by MetaPhat multivariate-GWAS using ASD and 8 genetically correlated trait summary statistics. Supplementary Table 7. A) 108 enriched (p < 0.05) Go terms are annotated and (B) 46 pathways on WikiPathway C) KEGG D) Reactome resources e) Tissue from the list of multivariate ASD SNPs found enrichments in neuron and nervous systems related data. Supplementary Table 8. ASD central SNP alleles are mapped to GEMMA genotypes called from 112 (49% females) WGS samples (45 (42% females) ASD probands). Phi coefficients are calculated between allele proportions where Chi-square test is applied to assess statistical importance. Indicated with *. Fisher's exact test is applied when Chi-square assumptions are violated. Supplementary Table 9. eQTL and sQTL related results of the ASD central associations relative to brain and nervous systems from EBI QTL catalog are captured via https://fivex.sph.umich.edu/. Study URLs are listed at the bottom of the table.