Type I error rates at various levels of residual correlations under homogeneous population.
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Two hundred nuclear families were simulated, with the number of children per family being drawn from a Beta distribution with mean 2. Type I error rate was estimated at nominal level 5% on 1,000 replicates, with various levels of polygenic correlation (ρa) and environmental correlation (ρe).
athe test site was linked to but not associated with the causal site.
bthe test site was neither linked to nor associated with the causal site.
Abbreviations: T, the proposed bivariate method; FBAT, the method FBAT-GEE [10] implemented in the software FBAT [24]; PBAT, the method FBAT-PC [9] implemented in the software PBAT [25]; QTDT, the method proposed by Abecasis et al. [23] and implemented in the software QTDT; UT, the univariate test in our previous study [18].
创建时间：
2013-02-21
