Twenty-one MC3 marker genes were associated with the GO-cellular component of endosomes and/or lysosomes.

The endosome/lysosome localization of each protein was defined by the COMPARTMENTS (Jensen) database. For survival analyses, the TCGA GBM mRNA-seq dataset (n = 155) and CGGA primary GBM dataset were used (n = 220) (gene expression low versus high cutoff: median expression; significance: log-rank p-value < = 0.05; n.a.: no information available for CTSL in the TCGA dataset). *Genes that have the following characteristics: endosome/lysosome is the most or one of the most likely localizations, and the correlation between expression and survival was significant or showing consistent trend in both TCGA and CGGA GBM datasets. **The Pearson correlation coefficients (r-values) between the expression (tpm) of designated genes were calculated using the TCGA GBM mRNA-seq dataset (n = 162).
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