SPathDB

SPathDB consists of 1689,868 spatial spots of 695 slices from 84 spatial transcriptome datasets of human and mouse, which involves 36 tissues, and also diseases such as cancer, and provides interactive analysis and visualization of the functional activities of 114,998 pathways across these spatial spots. SPathDB provides five flexible interfaces to retrieve and analyze pathways with highly variable functional activity across spatial spots, the distribution of pathway functional activities along pseudo-space axis, pathway-mediated spatial intercellular communications and the associations between spatial pathway functional activity and the occurrence of cell types. SPathDB will serve as a foundational resource for identifying functional features and elucidating underlying mechanisms of spatial heterogeneity.SPathDB 涵盖源自84套人源与小鼠源空间转录组（spatial transcriptome）数据集的695张切片，总计1689868个空间斑点（spatial spots），覆盖36种组织类型，同时包含癌症等多种疾病样本。该数据库可对这些空间斑点中的114998条通路（pathways）的功能活性开展交互式分析与可视化展示。SPathDB 提供五种灵活的交互接口，可用于检索分析跨空间斑点功能活性差异显著的通路、通路功能活性沿伪空间轴的分布特征、通路介导的空间细胞间通讯，以及空间通路功能活性与各类细胞类型出现情况的关联关系。SPathDB 将成为识别空间异质性（spatial heterogeneity）功能特征、阐明其潜在分子机制的基础性核心资源。

搜集汇总

背景与挑战

背景概述

SPathDB是一个综合性空间转录组数据库，整合了来自人类和小鼠84个数据集的695个切片中的168.9868万个空间点，涵盖36种组织和多种疾病（如癌症），涉及114,998条生物通路。该数据库提供五种交互式分析工具，用于探索功能活动中的空间异质性，包括空间可变通路、空间可变基因等分析功能。