The Sec7 family of the Dictyostelia.

The Sec7 family members in three taxonomic divisions of the Dictyostelia are listed. The D. discoideum genome [11] was searched for proteins containing a Sec7 domain (dictyBase, http://dictybase.org/index.html). The families were classified according to Casanova [46]. The domains listed were identified by Blast searches (http://blast.ncbi.nlm.nih.gov/Blast.cgi). The D. discoideum (D. d.) proteins were then used to search for homologues in the D. falciparum (D. f.) and P. pallidum (P. p.) genomes at http://sacgb.fli-leibniz.de/cgi/index.pl. D. falciparum belongs to group 1, P. pallidum is a member of group 2 and D. discoideum (D. d.) is a member of group 4. The homology search was done by Blast. DUF1981, DUF2339, domains of unknown function, present in predicted membrane proteins. MFS, Major-Facilitator-Superfamily, group of membrane proteins; TM, transmembrane; DUF1981, domain of unknown function, present in predicted membrane proteins, PH, PH-domain.