Expression analysis of C. elegans wild-type N2 and rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutants

Investigation of whole genome gene expression level changes in C. elegans rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutant compared to the wild-type N2 strain. The mutants have altered longevity phenotypes. The mutants analyzed in this study are further described in Di Chen, Patrick Wai-Lun Li, Benjamin A. Goldstein, Waijiao Cai, Emma Lynn Thomas, Fen Chen, Alan E. Hubbard, Simon Melov and Pankaj Kapahi, Germline Signaling Mediates the Synergistically Prolonged Longevity by Double Mutations in daf-2 and rsks-1 in C. elegans, Cell Reports (CELL-REPORTS-D-13-00388).本研究以野生型N2品系为对照，分析秀丽隐杆线虫（Caenorhabditis elegans）rsks-1、daf-2、daf-2 rsks-1、daf-16及daf-2 rsks-1突变体的全基因组基因表达水平变化。上述突变体均存在寿命表型异常。本研究涉及的突变体的详细信息，可参见以下文献：Di Chen、Patrick Wai-Lun Li、Benjamin A. Goldstein、Waijiao Cai、Emma Lynn Thomas、Fen Chen、Alan E. Hubbard、Simon Melov及Pankaj Kapahi发表于《细胞报告》（Cell Reports）的论文《生殖系信号介导秀丽隐杆线虫daf-2与rsks-1双突变体的协同延寿效应》，文献编号为CELL-REPORTS-D-13-00388。