Formulation and In-Vitro Evaluation of Gastroretensive Drug Delivery System of Ritonavir

The purpose of the research work was to develop a floating drug delivery system of Ritonavir in order to prolong the gastric residence time and increase its bioavailability. Gastroretensive retentive drug delivery system is designed with the aim to target the drug to its absorption site and to maintain the dosage form at that site for an extended period of time. To develop a floating Mucoadhesive tablet of ritonavir to prolong the gastric retention time for effective drug delivery system. Floating Mucoadhesive tablet of ritonavir was prepared successfully by direct compression method. Compatibility study of ritonavir with formulation ingredients was performed by DSC and FTIR results revealed that drug was compatible with all selected excipients. The present investigation was aimed to formulate floating drug delivery system using effervescent agent sodium bicarbonate and citric acid the tablet continuously floats for more than 12 h. Floating tablet was prepared using HPMC (K4M) carbopol 934.