This dataset contains the training, validation, and test data used for transcription factor (TF)–DNA binding prediction in the TFBindFormer framework. It integrates genomic DNA sequence bins with tran
BackgroundComputational de novo discovery of transcription factor binding sites is still a challenging problem. The growing number of sequenced genomes allows integrating orthology evidence with coreg
The family of the Nine amino acid Transactivation Domain, 9aaTAD family, comprises currently over 40 members. The 9aaTAD domains are universally recognized by the transcriptional machinery from yeast
Non-coding genetic variants/mutations can play functional roles in the cell by disrupting regulatory interactions between transcription factors (TFs) and their genomic target sites. For most human TFs
Table 6 indicates the average AUC score across ten classifiers where training data from one TF (rows) was used to train a classifier that classified TFBS for another TF (columns).