Atlas of the aging mouse intestine

In this study, we generated single-cell RNA sequencing (scRNA-seq) data from epithelial cells in the intestine, focusing on six distinct subsections during aging: the proximal small intestine, intermediate small intestine, distal small intestine, cecum, proximal colon and distal colon regions. Using a hashtag-labeled method, we aimed to create a comprehensive atlas of cellular changes during aging within these regions. Our objective is to uncover the underlying mechanisms of aging, leveraging the intestine as a model due to its highly proliferative nature. This dataset will provide valuable insights into the cellular dynamics of aging and contribute to the broader understanding of age-related processes. Single-cell RNA seq on epithelial cells from six different sections of the mouse intestine during aging本研究从小鼠肠道上皮细胞中获取单细胞RNA测序（single-cell RNA sequencing, scRNA-seq）数据，聚焦衰老过程中的六个不同肠道区段：近端小肠、中段小肠、远端小肠、盲肠、近端结肠及远端结肠区域。本研究采用hashtag标记法，旨在构建上述区段内衰老过程中细胞变化的综合细胞图谱。鉴于肠道具有高度增殖的特性，本研究以肠道作为衰老研究模型，旨在揭示衰老的潜在分子机制。本数据集将为衰老过程中的细胞动态变化提供宝贵的研究视角，并助力学界更全面地理解衰老相关的生物学进程。本数据集涵盖衰老过程中小鼠肠道六个不同区段上皮细胞的单细胞RNA测序数据。