Effect of gene inactivation by RNAi on sensitivity to pathogen infection and arsenic stress.

Values represent survival of RNAi-treated animals challenged with P. aeruginosa infection or arsenic-mediated oxidative stress. Survival analysis is depicted as mean time to death relative to control animals treated with a vector construct with no RNAi target (mutant TDmean / control TDmean). *, p≤0.001 compared to control; Kaplan Meier non-parametric comparisons and a Logrank test. #, genes that, when inactivated by RNAi, did not significantly affect survival on P. aeruginosa but were colonized by P. aeruginosa to a significantly higher degree (see Figure S4A).