A 105-kDa protein is required for yeast mitochondrial RNase P activity.
收藏PubMed Central1992-10-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC50236/
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资源简介：
RNase P from the mitochondria of Saccharomyces cerevisiae was purified to near homogeneity > 1800-fold with a yield of 1.6% from mitochondrial extracts. The most abundant protein in the purified fractions is, at 105 kDa, considerably larger than the 14-kDa bacterial RNase P protein subunits. Oligonucleotides designed from the amino-terminal sequence of the 105-kDa protein were used to identify and isolate the 105-kDa protein-encoding gene. Strains carrying a disruption of the gene for the 105-kDa protein are viable but respiratory deficient and accumulate mitochondrial tRNA precursors with 5' extensions. As this is the second gene known to be necessary for yeast mitochondrial RNase P activity, we have named it RPM2 (for RNase P mitochondrial). IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-10-15
