Hepatic PPARalpha is critical in the metabolic adaptation to sepsis

Sepsis induces a metabolic shift from glucose to fatty acid utilization that is key to survival for the organism. Here we used microarray analysis to characterize hepatic gene expression in conditions mimicking sepsis. Wild type or whole-body Ppara-KO mice were infected with E.coli to induce sepsis. Mice were killed 16 hours after infection and livers were removed for transcriptomic analysis. Each array is 1 biological replicate