Bioinspired Synthesis of Platensimycin from Natural ent-Kaurenoic Acids
收藏Figshare2023-06-20 更新2026-04-28 收录
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https://figshare.com/articles/dataset/Bioinspired_Synthesis_of_Platensimycin_from_Natural_i_ent_i_-Kaurenoic_Acids/23545416
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资源简介：
The biomimetic formal synthesis of the antibiotic platensimycin for the treatment of infection by multidrug-resistant bacteria was accomplished starting from either ent-kaurenoic acid or grandiflorenic acid, each of which is a natural compound available in multigram scale from its natural source. Apart from the natural origin of the selected precursors, the keys of the described approach are the long-distance functionalization of ent-kaurenoic acid at C11 and the efficient protocol for the A-ring degradation of the diterpene framework.
创建时间：
2023-06-20
