The Runx1 transcription factor is essential for hematopoietic differentiation and mutations underlie various leukemias. Here we demonstrate a role for Runx1 in the MCF10 cell series model of breast ca
BT474 human breast carcinoma cells were obtained from American Type Culture Collection (ATCC, Manassas, VA). The cells were grown in Dulbecco's modified eagle medium (DMEM, Thermo Fisher Scientific In
Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells.
We measured changes in H3K9me3 after treatment of human breast cancer cell lines with abemaciclib Overall design: Examination of changes in H3K9me3 in breast cancer cell lines after treatment with abe
We performed a CRISPR-based functional genetic screen targeting CTCF binding elements (CBEs) located in the vicinity of ERα-bound enhancers. The screen identified four functional CBEs whose targeting