TDP-43 regulates cancer-associated microRNAs
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TDP-43 regulates cancer-associated microRNAs
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创建时间：
2016-08-02
相关数据集
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear TDP-43. Here we identify that TDP-43 regulates expression of the neuronal growth-associated fa
NIAID Data Ecosystem130
TDP-43 regulates cancer-associated microRNAs
MicroRNAs (miRNAs) play important roles in a wide range of cellular processes. Aberrant regulation of miRNA genes contributes to human diseases, including cancer. The TAR DNA binding protein 43 (TDP-4
NIAID Data Ecosystem50
Loss of function mutations in TDP-43 modifier genes.
Loss of function mutations in TDP-43 modifier genes.
Figshare2019-12-13 更新40
TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation
TDP-43 (TAR DNA binding protein 43) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that has been found to play an important role in neurodegenerative diseases. TDP-43’s involvement in nuclear fa
NIAID Data Ecosystem60
TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression. TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression
Identified TDP-43 targets in rat cortical neurons, many related to the CREB pathway Overall design: First application of TRIBE in mammalian system, used human ADAR2 catalytic domain for the experiment
NIAID Data Ecosystem50
