A Nucleophilic Strategy for Enantioselective Intermolecular α‑Amination: Access to Enantioenriched α‑Arylamino Ketones

The
enantioselective addition of anilines to azoalkenes was accomplished
through the use of a chiral phosphoric acid catalyst. The resulting
α-arylamino hydrazones were obtained in good yields and excellent
enantioselectivities and provide access to enantioenriched α-arylamino
ketones. A serendipitous kinetic resolution of racemic α-arylamino
hydrazones is also described.