Mechanical Regulation of Stem Cell Proliferation and Fate Decisions by their Differentiated Daughters
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=58c6e5beeeb13f658b39cf45b875fd35
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资源简介：
RNAseq analysis of suprabasal cells in the epidermis of control and K10rtTA;TRESpastin (which depolymerize microtubules) at E16.5 were performed. We observed the premature differentiation of the barrier and increased actomyosin contractility in suprabasal differentiated cells upon microtubule disruption compared to control, and proved the increased actomyosin contractility caused by microtubule depolymerization leads to basal stem cell hyperproliferation during epidermal development.
提供机构：
Duke University
创建时间：
2022-02-20
