Joint coding of visual input and eye/head position in V1 of freely moving mice dataset

Visual input during natural behavior is highly dependent on movements of
the eyes and head, but how information about eye and head position is
integrated with visual processing during free movement is unknown, since
visual physiology is generally performed under head-fixation. To address
this, we performed single-unit electrophysiology in V1 of freely moving
mice while simultaneously measuring the mouse’s eye position, head
orientation, and the visual scene from the mouse’s perspective. From these
measures, we mapped spatiotemporal receptive fields during free movement
based on the gaze-corrected visual input. Furthermore, we found a
significant fraction of neurons tuned for eye and head position, and these
signals were integrated with visual responses through a multiplicative
mechanism in the majority of modulated neurons. These results provide new
insight into coding in mouse V1, and more generally provide a paradigm for
performing visual physiology under natural conditions, including active
sensing and ethological behavior.