Single Cell Omics Resolves Transcriptional Alterations in Sjogren's Syndrome

Single cell omics resolves transcriptional alterations in Sjogren's Syndrome. This data compares the single cell transcriptional profiles of the minor salivary glands between Sjogren’s Syndrome patients and non-Sjogren’s Syndrome subjects. Portions of this data were reported in two separate publications: Huang & Perez, et al., 2021 Nature Medicine and Yin, et al., 2021, Frontiers in Immunology . ]]>
Inclusion Criteria: older than 4 years, affected or suspected of being affected with a disease/disorder involving the salivary glands, or a relative of a patient who is affected with a salivary gland disease/disorder. 18 years or older with active hepatitis with or without sicca symptoms. 18 years or older, healthy, agree to have blood, urine, saliva or other tissue samples collected and studied.Exclusion Criteria: not able to give consent/assent or parental/guardian consent
NIH employees who directly report to the principal investigator
significant concurrent medical condition or other circumstances that may affect the participant’s ability to tolerate or complete the study, such as concurrent chemotherapy or bleeding disorders.
Additional Exclusion Criteria for Healthy Volunteers (HV):
pregnancy
sicca symptoms
HIV, hepatitis B or C infection
chronic medical illness, other than well-controlled hypertension or hyperlipidemia
chronic use of medications, with the exception of oral contraception, hormone replacement therapy, aspirin, antihypertensive and antilipemic]]>