Structural mechanisms of protein of biomedical and biotechnological application: pathological processes, targeted therapies, and enzyme desi

The Spanish Macromolecular Structural Groups in Granada, Almeria and Valencia present a continuation of their previous proposal (MX-2527) with the aim to form a strong core of scientists devoted to deciphering the structure and molecular mechanisms of proteins and protein complexes of biomedical and biotechnological interest. Among their objectives are deciphering the molecular basis of human pathologies and developing targeted therapies to designing new protein catalysts. This joint proposal follows the advice of the ESRF evaluation committee for merging two Teams with a long trajectory in protein crystallography and synchrotron usage, the Oriental Andalusian Team (Mx2454) led by JA Gavira and the Valencian Team with (Mx2452) led by S Ramón-Maiques. Based on the experience of the first year, we confirmed that this collaboration reinforces the crystallography teams and helps to better use synchrotron resources.