File S1 - Pathway Analysis for Genome-Wide Association Study of Lung Cancer in Han Chinese Population

Table S1. The rank of pathways based on combined dataset of Nanjing and Beijing studies. Table S2. Sensitivity analysis of pathway analysis for genes defined by SNPs within 20 kb upstream or downstream. Table S3. Gene overlaps between 4 indentified pathways for all genes defined by BioCarta database or genes with significant representative SNPs (P<0.05)a. (a) The bottom-left of the symmetric matrix is the number of overlap genes between pair-wise pathways and their total gene number. The top-right part is the overlap rate between pair-wise pathways (%). Table S4. Genes with significant representative SNPs (P≤0.01) contributed to multiple pathways. (a) Derived from logistic regression model with adjustment for age, gender, pack-year of smoking and principal components in combined dataset of Nanjing and Beijing studies. Table S5. The results of sensitivity analysis for 4 identified pathway after removing significant overlapping genes (PAK1, PIK3R1, PTK2 and PTK2B).
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