Mean fitness and physical function change from baseline in both the intent-to-treat and per protocol cohorts.

The Group * Time interaction tests for group differences in response to exercise. The Best Fitting Model was assessed using an orthogonal contrast to test the shape of the dose-response. Both the interaction and the contrast had to reach a level of significance to be adopted as the best fitting model. In the ITT cohort, eleven individuals did not return for follow-up physical function testing and an additional six refused follow-up cardiopulmonary exercise test. Nine individuals did not return for follow-up cognitive testing. All values mean (standard deviation) unless otherwise noted. Mean fitness and physical function change from baseline in both the intent-to-treat and per protocol cohorts.