Fold change of retinoid metabolism-related gene expression in skin of mice after two weeks topical treatment with retinoid receptor-specific antagonists.

1BMS614; 2UVI2041; 3BMS493; 4UVI3003; 5retinoid target genes; 6target genes not involved in retinoid signaling; 7gene also relevant in epidermal homeostasis; UDL, under detection limit. Fold change data are expressed as mean ± SEM (n≥5) and were determined in skin specimens of topically treated mice by qRT-PCR. Statistical significance (p) was tested using one-way ANOVA followed by Dunnett’s post-test. *p<0.05, #p<0.01, §p<0.001, versus control (acetone).