RNA-seq analyses of human ameloblastoma and odontogenic keratocyst

Ameloblastoma (AM) is a benign but locally invasive tumor with high recurrence rates. Invasive behavior of the odontogenic tumor results in destruction of the adjacent jawbone and formation of daughter cysts, hindering the complete elimination of cancer cells during surgery. To understand the underlying mechanism of AM invasion, we compared the transcriptome of AM with that of an odontogenic keratocyst (OKC), a dental epithelium-originated cyst with non-invasive characteristics. Overall design: RNA was extracted from three ameloblastoma and three odontogenic keratocyst tissues collected from individual patients and subjected into RNA-seq anlaysis.