Gut Microbiota Diversity in Osteoporosis Patients with Different Syndromes

The occurrence of osteoporosis is closely related to alterations in the gut microbiota. Traditional Chinese Medicine (TCM) classifies osteoporosis into distinct subtypes based on clinical symptomatology and underlying pathological patterns, which may reflect differences in host physiology and metabolic milieu. However, the characteristics of the gut microbiota across these TCM subtypes remain poorly understood. This study aims to investigate whether TCM-based classification of osteoporosis corresponds to specific gut microbial and metabolic profiles, thereby providing a microbiological basis for syndrome differentiation.