Blood memory CD8 T cell phenotypes in lung cancer patients predict immune checkpoint treatment responses
收藏NIAID Data Ecosystem2026-05-02 收录
下载链接：
https://zenodo.org/record/10867208
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资源简介：
Rscript for figure generation and data analysis:
GenerateFigures.R
Seurat objects containing processed data after quality control:
NCCS_For_Zenodo.RDS - NCCS discovery cohort.
Pavia_For_Zenodo.RDS - Pavia validation cohort.
RDS files containing DEGs or differentially abundant surface markers:
TestResults2Groups.rds - Cell type specific LTR vs Non Responder DEG
TestResults2GroupsADT.rds - Cell type specific LTR vs Non Responder differential surface markers
TestResults2GroupsLungOnly.rds - Cell type specific LTR vs Non Responder DEG on lung samples only
TestResults2GroupsLungOnlyADT.rds - Cell type specific LTR vs Non Responder differential surface markers on lung samples only
TestResults3Groups.rds - Cell type specific LTR vs R vs Non Responder differential DEG
TestResults3GroupsGeneralADT.rds - Across cell type LTR vs R vs Non Responder differential surface markers
TestResults2GroupsGeneralRNA.rds - Across cell type LTR vs Non Responder DEG
TestResults2GroupsGeneralADT.rds - Across cell type LTR vs Non Responder differential surface markers
TestResults2GroupsLungOnlyGeneralRNA.rds - Across cell type LTR vs Non Responder DEG on lung samples only
TestResults2GroupsLungOnlyGeneralADT.rds - Across cell type LTR vs Non Responder differential surface markers on lung samples only
TestResults3GroupsGeneralRNA.rds - Across cell type LTR vs R vs Non Responder differential DEG
TestResults3GroupsGeneralADT.rds - Across cell type LTR vs R vs Non Responder differential surface markers
Logistic regression models trained on the NCCS discovery cohort:
PerCellPredictions * - Celltype specific models predicting either LTR, R or control group trained on all NCCS samples
PerCellPredictions_2Groups_LungOnly * - Celltype specific models predicting either LTR or NonResponder group, trained on lung samples only.
PerCellPredictions_2Groups_ * - Celltype specific models predicting either LTR or NonResponder trained on all NCCS samples
创建时间：
2024-11-22
