首页/数据集/H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers. H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers

H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers. H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers

NIAID Data Ecosystem2026-03-10 收录

剪接体靶向治疗

癌症药物开发

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA375127 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2017-02-16

抗癌药物耐药突变鉴定

癌症药物开发

Identifying resistance mutations in a drug target provides crucial information. Lentiviral transduction creates multiple types of mutations due to the error-prone nature of the HIV-1 reverse transcrip

NIAID Data Ecosystem80

The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan -Hsp90 Inhibition

Hsp90亚型选择性抑制

癌症药物开发

The 90 kD heat shock proteins (Hsp90) are molecular chaperones that are responsible for the folding of select proteins, many of which are directly associated with cancer progression. Consequently, inh

NIAID Data Ecosystem50

Design and Development of IKZF2 and CK1α Dual Degraders

蛋白靶向降解疗法

癌症药物开发

Lenalidomide achieves its therapeutic efficacy by recruiting and removing proteins of therapeutic interest through the E3 ligase substrate adapter cereblon. Here, we report the design and characteriza

Figshare2023-12-12 更新10

In Vivo Activity and Pharmacokinetics of Nemorosone on Pancreatic Cancer Xenografts

癌症药物开发

抗癌化合物

Pancreatic cancer is one of the leading cancer-related causes of death in the western world with an urgent need for new treatment strategies. Recently, hyperforin and nemorosone have been described as

NIAID Data Ecosystem80

A novel regulatory mechanism of U2 spliceosome proteostasis that controls the transcriptome and therapy response in cancer [RNAseq_CUTLL1_shSF3B1.1]. A novel regulatory mechanism of U2 spliceosome proteostasis that controls the transcriptome and therapy response in cancer [RNAseq_CUTLL1_shSF3B1.1]

剪接体靶向治疗

白血病转录组

Aberrant splicing is an important cause of cancer, and the production of noncanonical, cancer-specific, mRNA transcripts associate with transformation. Studies have focused on characterizing the effec

NIAID Data Ecosystem30

H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers. H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers

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