Laboratory investigations in the chronic p.o. administration of H2 experiment with type 2 diabetic db/db mice.

Data are expressed as mean ± standard error (SE). Comparisons with control group were performed by Dunnett’s multiple comparison test. As described in Materials and Methods, we lost several mice by natural death after 120 days in each group and thus the number of mice for laboratory investigations are 6 (control), 4 (HHW) and 6 (NHW). HHW = high content hydrogen water; NHW = natural hydrogen water; AUC = area under the curve; IPGTT = intraperitoneal glucose tolerance test; HDL = high-density lipoprotein; LDL = low-density lipoprotein; NEFA = free fatty acids.