PHA665752 resistant EBC-1 cell lines. Homo sapiens

Acquired resistance (AR) is a major problem in lung cancer treatment and it is an important drawback in tyrosine kinase inhibitors (TKIs)-based therapeutics. In this context, it is important to understand the molecular determinants underlying this phenomenon.The EBC1 cells, which are sensitive to TKIs against MET, were used to generate multiple clones with AR to a MET-TKI. Whole exome sequencing and RNA sequencing analysis were used to scrutinize the genetic and molecular characteristics of the resistant cells.