Dynamic upregulation of retinoic acid RA signal in the early postnatal murine heart promotes cardiomyocyte cell cycle exit and maturation [PRVCMs_Cont-ATRA]

Retinoic acid (RA), the major active metabolite of vitamin A, is essential for organogenesis, homeostasis, and tissue morphogenesis. Despite the importance of RA signaling in embryo heart development, little is known about its function in the early postnatal period. For a comprehensive transcriptional evaluation of the effect of RA signaling on neonatal cardiomyocyte cell cycle arrest and maturation, we performed RNA-seq analysis of cultured perinatal cardiomyocytes treated with all-trans retinoic acid (ATRA) in vitro.视黄酸（Retinoic acid, RA）是维生素A的主要活性代谢产物，对器官发生、机体稳态维持及组织形态建成至关重要。尽管RA信号通路在胚胎心脏发育中具有重要意义，但目前学界对其在出生后早期阶段的功能仍所知甚少。为全面评估RA信号通路对新生心肌细胞周期阻滞与成熟的调控效应，我们对体外经全反式视黄酸（all-trans retinoic acid, ATRA）处理的培养围产期心肌细胞开展了RNA测序（RNA-seq）分析。