Transcription profiling of lungs of wild type and Mg-delta strain of fibrillin-1deficient mice to identify pathways that are critical for normal alveolar septation

The Mg-delta strain of fibrillin-1 deficient mice display an early defect in alveolar septation. This study attempts to identify expression patterns in the mutant mouse lung compared to their wild-type littermates that suggest pathways that are critical for normal septation. This experiment focuses on postnatal days 1 and 5. Other time points will be added at a later date.原纤维蛋白-1（fibrillin-1）缺陷小鼠的Mg-delta品系，在肺泡隔形成阶段存在早期发育缺陷。本研究旨在对比该突变型小鼠肺组织与其野生型同窝仔鼠的基因表达谱，以识别对正常肺泡隔形成至关重要的信号通路。本实验聚焦于出生后第1天和第5天的样本，后续将补充其他时间节点的实验数据。