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Transcriptomic analysis of human gastric cancer cell lines following T-DXd treatment

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE245851
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Despite the clinical success of trastuzumab deruxtecan (T-DXd) in treating HER2-positive gastric cancers (GCs), its precise immunomodulatory mechanisms remain elusive. This study investigates T-DXd's immune-related actions in GC cells through RNA sequencing. NCI-N87, and SNU-484 cell lines were treated with 1 ug/ml of trastuzumab or T-Dxd for 72 h followed by RNA isolation for subsequent RNA sequencing.
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2024-12-13
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