High dose wIFN-α significantly induced intrahepatic expression of T cell, NK cell and IFN-γ response genes.

RNA-Seq data for genes selectively induced by high dose (100 μg) but not by low dose (20 μg) wIFN-α. The full list of genes induced by high dose wIFN-α only (n = 468 genes) is displayed in S8C Table.aFold-change ratio values relative to time-matched placebo animals (n = 5–12) are displayed, with underlining denoting statistical significance (FDR placebo, the fold change ratio was calculated by 1 x (treated/placebo), i.e. 1.50 equals a 50% increase in treated vs. placebo. For genes where wIFN-treated bHugo symbols are used for gene names. Alternative gene names; CXCL9: MIG, PDCD1: PD-1, TBX21: T-bet, KLRK1: NKG2D.cFold-change ratio for PLA2G2A at week 11 was close to statistical significance (FDR = 0.063).W: week.High dose wIFN-α significantly induced intrahepatic expression of T cell, NK cell and IFN-γ response genes.