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Tissue-resident memory T cells overcome tolerance to renal autoantigen and orchestrate immune-mediated nephritis

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP475457
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资源简介:
Differential transcriptome analysis of activated splenic CD8 T cells revealed a hybrid phenotype in the context of renal autoantigen crosspresentation, combining hallmarks of activation and T cell dysfunction. Overall design: OT-1 cells were isolated (FACS sorting) from spleens and lymph nodes of 2 wildtype and 2 NOH mice 7 days after adoptive transfer and activating LM-OVA infection and analyzed using scRNA-seq (10x platform).
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2024-07-30
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