Statistical significant result on the volumetric comparison between groups of Tc1 Down Syndrome mouse and wild type, result obtained both from our multi-atlas framework as well as the single-atlas based method using all atlases in the database.

STEPS: structural label obtained from the result of our framework using STEPS label fusion algorithm. A1–A9: structural label obtained from the result of single-atlas based segmentation method on each one of the atlas in the MRM NeAt database. A two-tailed paired t-test was performed on each of the 40 structures. Multiple comparisons are corrected with false discovery rate q = 0.05. Error bars representing standard deviation. (*: significant difference was discovered between the wild type and the transchromosomic group.).