RNA binding sites of alternate exon junction complex proteins RNPS1 and CASC3. Homo sapiens strain:HEK293

The exon junction complex (EJC) deposited upstream of mRNA exon junctions during pre-mRNA splicing shapes the structure, composition and fate of all spliced mRNAs. The goal of the study was to identify RNAs preferentially bound to EJC proteins RNPS1 and CASC3, which bind peripherally to the EJC core in a mutually exclusive manner. Both RNPS1 and CASC3 have been implicated in regulating mRNA translation and decay, and RNPS1 copy number variation is linked to intellectual disability and autism.