RefAHL: A curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products

Some bacteria use acyl-homoserine lactone (AHL) signals in quorum sensing, a type of cell-cell communication. Here we present “RefAHL”, a curated collection of LuxI-type AHL synthases with their AHL structures and associated metadata. RefAHL is publicly available as a community resource to help catalog LuxI-type diversity encoded in (meta)genomic data., The RefAHL dataset was collected, assembled and curated by humans from the public scientific literature., , # RefAHL: A curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products

Dataset DOI: [10.5061/dryad.866t1g21s](10.5061/dryad.866t1g21s)

## Description of the data and file structure

Here we curate a list of previously published LuxI homologs, which have been experimentally demonstrated to synthesize an acyl homoserine lactone (AHL) signal of well-supported structure. We refer to this collection as “RefAHL” and will update the collection when new LuxI-AHL signals are defined.

Contact Amy Schaefer ([[e-mail]](mailto:[e-mail])) or Aaron Puri ([[e-mail]](mailto:[e-mail])) with any questions or to submit newly defined LuxI-AHL signal pairs.

There are two associated files (note that date suffixes in YYYYMMDD format will change in future versions).

### Files and variables

#### File: RefAHL\_complete\_revYYYYMMDD.xlsx

**Description:** The RefAHL_complete_revYYYYMMDD.xlsx file has Tab 1 (\"RefAHL LuxI-...,