RefAHL: A curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products
收藏资源简介：
Some bacteria use acyl-homoserine lactone (AHL) signals in quorum sensing, a type of cell-cell communication. Here we present âRefAHLâ, a curated collection of LuxI-type AHL synthases with their AHL structures and associated metadata. RefAHL is publicly available as a community resource to help catalog LuxI-type diversity encoded in (meta)genomic data., The RefAHL dataset was collected, assembled and curated by humans from the public scientific literature., , # RefAHL: A curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products Dataset DOI: [10.5061/dryad.866t1g21s](10.5061/dryad.866t1g21s) ## Description of the data and file structure Here we curate a list of previously published LuxI homologs, which have been experimentally demonstrated to synthesize an acyl homoserine lactone (AHL) signal of well-supported structure. We refer to this collection as âRefAHLâ and will update the collection when new LuxI-AHL signals are defined. Contact Amy Schaefer ([amyschae@uw.edu](mailto:amyschae@uw.edu)) or Aaron Puri ([a.puri@utah.edu](mailto:a.puri@utah.edu)) with any questions or to submit newly defined LuxI-AHL signal pairs. There are two associated files (note that date suffixes in YYYYMMDD format will change in future versions). ### Files and variables #### File: RefAHL\_complete\_revYYYYMMDD.xlsx **Description:**Â The RefAHL_complete_revYYYYMMDD.xlsx file has Tab 1 (\"RefAHL LuxI-...,
部分细菌在群体感应（quorum sensing）——一种细胞间通信方式——中使用酰基高丝氨酸内酯（acyl-homoserine lactone, AHL）信号分子。本研究公开了"RefAHL"：一套经人工审编的LuxI型AHL合酶集合，包含其对应的AHL结构与相关元数据（metadata）。RefAHL作为公共社区资源开放获取，旨在助力对（宏）基因组（metagenomic）数据中编码的LuxI型酶多样性进行编目。 RefAHL数据集由科研人员人工从公开科学文献中收集、整理并审编。 # RefAHL：经人工审编的群体感应参考数据集，关联多样的LuxI型信号合酶与其酰基高丝氨酸内酯产物 数据集DOI：[10.5061/dryad.866t1g21s] ## 数据与文件结构说明 本数据集整理了此前已发表的LuxI同源蛋白，这些蛋白经实验验证可合成结构明确的酰基高丝氨酸内酯（AHL）信号分子。我们将该集合命名为"RefAHL"，后续在新的LuxI-AHL信号对被确定时，将对该集合进行更新。 如有疑问或提交新定义的LuxI-AHL信号对，请联系Amy Schaefer（邮箱：amyschae@uw.edu）或Aaron Puri（邮箱：a.puri@utah.edu）。 本数据集附带两个相关文件（请注意：文件名中以YYYYMMDD格式标注的日期后缀将在后续版本中更新）。 ### 文件与变量说明 #### 文件：RefAHL_complete_revYYYYMMDD.xlsx **说明：** RefAHL_complete_revYYYYMMDD.xlsx包含工作表1（"RefAHL LuxI-..."）
