SGLT2 inhibition and inflammasome pathway and diabetic nephropathy

This study investigated the effects of sodium glucose cotransport 2 (SGLT2) inhibition on cardiac redox homeostasis and inflammation in an experimental model of DN. Male C57BL/6J mice were fed either standard chow (SC) or high-fat diet (HFD) for 16 weeks, with the HFD animals receiving streptozotocin (40 mg/kg) at week 8. At week 17, mice were divided into four groups: Sham, Sham+SGLT2i, DN, and DN+SGLT2i (empagliflozin 35 mg/kg for 8 weeks), and their cardiac tissues were analyzed for oxidative stress markers and inflammatory mediators.