Neutralizing properties of vaccine-elicited CD4bs-directed MAbs.

(A) Neutralization activity of four isolated VH1.23-using MAbs from the current study, two previously described non-VH1.23-using NHP MAbs against the CD4bs, and VRC01 were tested against a panel of viruses using the TZM-bl pseudovirus assay. The results are shown as neutralization IC50 values, that is, the MAb concentration inhibiting 50% of viral entry. The IC50 values are color-coded where red indicates (<0.1 µg/ml), dark orange (0.1–1 µg/ml), light orange (1–10 µg/ml), yellow (10–50 µg/ml) and white (>50 µg/ml).