Data from Head-Neck-PET-CT

This collection contains FDG-PET/CT and radiotherapy planning CT imaging data of 300 patients from four different institutions in Québec with histologically proven head-and-neck cancer (H&N) All patients had pre-treatment FDG-PET/CT scans between April 2006 and November 2014, and within a median of 18 days (range: 6-66) before treatment (Note: date in the TCIA images have been changed in the interest of deidentification; the same change was applied across all images, preserving the time intervals between serial scans). For 93 of the 300 patients (31 ), the radiotherapy contours were directly drawn on the CT of the FDG-PET/CT scan by expert radiation oncologists and thereafter used for treatment planning. For 207 of the 300 patients (69 ), the radiotherapy contours were drawn on a different CT scan dedicated to treatment planning and were propagated/resampled to the FDG-PET/CT scan reference frame using intensity-based free-form deformable registration with the software MIM® (MIM software Inc., Cleveland, OH).Patients with recurrent H&N cancer or with metastases at presentation, and patients receiving palliative treatment were excluded from the study. From the 300 patients, 48 received radiation alone (16 ) and 252 received chemo-radiation (84 ) with curative intent as part of treatment management. The median follow-up period of all patients was 43 months (range: 6-112). Patients that did not develop a locoregional recurrence or distant metastases during the follow-up period and that had a follow-up time smaller than 24 months were also excluded from the study. During the follow-up period, 45 patients developed a locoregional recurrence (15 ), 40 patients developed distant metastases (13 ) and 56 patients died (19 ).

本数据集包含来自魁北克四家不同医疗机构的300例经组织学确诊的头颈部肿瘤（head-and-neck cancer, H&N）患者的氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）及放射治疗计划CT影像数据。所有患者均于2006年4月至2014年11月期间接受治疗前FDG-PET/CT扫描，扫描时间距治疗的中位间隔为18天（范围：6~66天）。注：为实现去标识化，TCIA影像中的日期已被统一修改，所有影像均采用相同的修改规则，以保留系列扫描间的时间间隔。在300例患者中，93例（占比31%）的放射治疗靶区轮廓由资深放射肿瘤学家直接在FDG-PET/CT扫描的CT图像上勾画，并直接用于治疗计划制定。剩余207例（占比69%）患者的放射治疗靶区轮廓则是在专门用于治疗计划的独立CT扫描图像上勾画，随后借助MIM®软件（美国俄亥俄州克利夫兰市MIM软件公司）的基于强度的自由形变配准算法，将轮廓传播并重采样至FDG-PET/CT扫描的参考坐标系中。本研究排除了复发型头颈部肿瘤患者、初诊时已发生远处转移的患者，以及接受姑息治疗的患者。300例入组患者中，48例（占比16%）仅接受单纯放射治疗，252例（占比84%）接受旨在根治的放化疗联合方案作为治疗管理的一部分。所有患者的中位随访时长为43个月（范围：6~112个月）。此外，随访期间未出现局部区域复发或远处转移且随访时长不足24个月的患者也被排除出本研究。随访期间，共有45例患者出现局部区域复发（占比15%）、40例发生远处转移（占比13%）、56例死亡（占比19%）。